A SYNTHETIC LETHAL SCREEN FOR SNAIL-INDUCED ENZALUTAMIDE RESISTANCE IDENTIFIES JAK/STAT SIGNALING AS A THERAPEUTIC VULNERABILITY IN PROSTATE CANCER

A synthetic lethal screen for Snail-induced enzalutamide resistance identifies JAK/STAT signaling as a therapeutic vulnerability in prostate cancer

Despite substantial improvements in the treatment landscape of prostate cancer, the evolution of hormone therapy-resistant and metastatic prostate cancer remains a major cause of cancer-related death globally.The mainstay of treatment for advanced prostate cancer is targeting of androgen receptor signaling, including androgen deprivation therapy pl

read more


A Research for the Determination of the Relationship between Organizational Conflict Management and Organizational Alienation

Our study researched at which level organizational conflict affected organizational alienation and what kind of a relationship there is between organizational conflict dimensions and organizational alienation in the institutions reviewed by us.Our study also examined how organizational conflict and organizational alienation are influenced by the de

read more

Surface Functionalization of Magnetite Nanoparticles for Remediation Enhancement of Phenol from Aqueous Solutions

Phenol is a toxic pollutant generated by industries.It can diminish the supply of clean water and is hazardous to Beauty Kit human health.Hence, an effective abatement method is important to remove phenol from water sources.The following amine-functionalized magnetite nanoparticles, ethylenediamine (EDA), diethylenetriamine (DETA), triethylenetetra

read more